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Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma

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Introduction: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC). Although multiple pharmacological HDAC inhibitors (HDACis) have been developed. none is available in human HCC. Objectives: To investigate the pharmacological effects of a fangchinoline derivative HL23. https://www.miabellesbabyes.shop/product-category/me-st-patricks-day-top/
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