Abstract Antigen escape relapse is a major challenge in targeted immunotherapies. including CD19- and CD22-directed chimeric antigen receptor (CAR) T-cell for B-cell acute lymphoblastic leukemia (B-ALL). To identify tumor-intrinsic factors driving antigen loss. we perform single-cell analyses on 61 B-ALL patient samples treated with CAR T cells. https://parisnaturalfoodes.shop/product-category/love-butter/