The gene encoding PDX1 (pancreatic duodenum homeobox 1). the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic β-cells. clusters with two closely related homeobox genes (Gsh1 and Cdx2/3). all of them belonging to the ParaHox gene family. https://www.roneverhart.com/Nef-Rune/